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Inside Cover: Naphthyridyl‐Substituted 4,4‐Difluoro‐4‐bora‐3a,4a‐diaza‐ s ‐indacene (BODIPY) Luminophores: Photophysics and Application as Molecular Imaging Probes in Live Cells (Asian J. Org. Chem. 9/2013)
Author(s) -
Martin Aaron,
Moriarty Roisin D.,
Long Conor,
Forster Robert J.,
Keyes Tia E.
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201390025
Subject(s) - bodipy , chemistry , fluorescence , stokes shift , photochemistry , aggregation induced emission , aqueous medium , quenching (fluorescence) , aqueous solution , live cell imaging , pegylation , alkyl , organic chemistry , cell , biochemistry , polyethylene glycol , physics , quantum mechanics
Fluorescent Probes The synthesis and photophysics of a family of BODIPY derivatives with a naphthyridine at the C8 position and alkyl, bromo, or dimethylaminoaryl groups at the C2 and C6 positions of the BODIPY core are described by Tia E. Keyes and co‐workers in their Full Paper on page 763 ff. The NIR emission of the dimethylaminoaryl compounds is Stokes‐shifted and strongly solvent dependent. The emission and Stokes shift are maintained in aqueous media. PEGylation of these compounds renders them water soluble and cell permeable. Their Stokes‐shifted fluorescence makes them less prone to self‐quenching within live cells than conventional BODIPY fluorophores.