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Inside Cover: Organocatalytic Enantioselective Morita–Baylis–Hillman Reaction of Maleimides with Isatins (Asian J. Org. Chem. 7/2013)
Author(s) -
Chauhan Pankaj,
Chimni Swapandeep Singh
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201390019
Subject(s) - chemistry , organocatalysis , enantioselective synthesis , maleimide , nucleophile , electrophile , baylis–hillman reaction , yield (engineering) , nitroaldol reaction , organic chemistry , catalysis , combinatorial chemistry , materials science , metallurgy
Organocatalysis Maleimides are known to be very good electrophiles, dienophiles, and dipolarophiles. In their Full Paper on page 586 ff. , Pankaj Chauhan and Swapandeep Singh Chimni demonstrate that maleimide derivatives can be used as nucleophilic partners in an efficient organocatalytic Morita‐Baylis‐Hillman reaction with isatins catalyzed by β‐isocupreidine. This reaction gives chiral 3‐substituted‐3‐hydroxyoxindoles in high yield and excellent enantioselectivity.