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Cover Picture: Oxygen‐promoted Palladium‐on‐Carbon‐catalyzed Ligand‐free Suzuki Reaction for the Synthesis of Heterobiaryls in Aqueous Media (Asian J. Org. Chem. 6/2013)
Author(s) -
Rao Xiaofeng,
Liu Chun,
Xing Yang,
Fu Yao,
Qiu Jieshan,
Jin Zilin
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201390015
Subject(s) - chemistry , suzuki reaction , catalysis , palladium , coupling reaction , ligand (biochemistry) , combinatorial chemistry , aqueous solution , organic chemistry , biochemistry , receptor
The palladium‐catalyzed Suzuki reaction has become a “classic” in organic synthesis. However, the influence of oxygen on the cross‐coupling reaction has not been fully investigated. In their Full Paper on page 514 ff., Chun Liu and co‐workers report a highly efficient protocol for the synthesis of heterobiaryls by a Pd/C‐catalyzed Suzuki reaction under aqueous, aerobic, and ligand‐free conditions. Control experiments demonstrate that this heterogeneous Suzuki reaction is promoted by oxygen. The method is operationally simple and the Pd/C catalyst is reusable.