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Inside Cover: Lewis‐Acid‐Catalyzed Intramolecular Aza‐Friedel–Crafts Reaction of N‐tert‐ Butanesulfinyl Imines: Efficient Synthesis of Optically Active 9‐Aminofluorene Derivatives (Asian J. Org. Chem. 1/2013)
Author(s) -
Li Yi,
Xu MingHua
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201390001
Subject(s) - chemistry , friedel–crafts reaction , intramolecular force , lewis acids and bases , context (archaeology) , optically active , organocatalysis , alkylation , catalysis , stereoselectivity , combinatorial chemistry , organic chemistry , enantioselective synthesis , paleontology , biology
Optically pure 9‐aminofluorene derivatives are fascinating in the context of biological materials and medicinal chemistry. However, stereoselective methods to access these compounds are rare. In their Communication on Page 50 ff., Ming‐Hua Xu and co‐workers disclose a simple Lewis‐acid‐catalyzed asymmetric intramolecular aza‐Friedel‐Crafts alkylation approach that enables the efficient construction of enantioenriched 9‐aminofluorene skeletons. This work will provide opportunities for future applications of chiral 9‐aminofluorene derivatives.