Synthesis of Substituted Pyrazoles from Vinylhydrozones via Bromoamination and Hydroamination with 2,2,6,6‐Tetramethylpiperidine‐1‐oxyl and  N ‐Bromosuccinimide | Zendy

Sar Dinabandhu | Zendy; Paul Rajesh | Zendy; Sengoden Mani | Zendy; Punniyamurthy Tharmalingam | Zendy

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Synthesis of Substituted Pyrazoles from Vinylhydrozones via Bromoamination and Hydroamination with 2,2,6,6‐Tetramethylpiperidine‐1‐oxyl and N ‐Bromosuccinimide

Author(s) -

Sar Dinabandhu,

Paul Rajesh,

Sengoden Mani,

Punniyamurthy Tharmalingam

Publication year - 2014

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201300294

Subject(s) - chemistry , n bromosuccinimide , amination , hydroamination , regioselectivity , oxidative phosphorylation , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis , halogenation , biochemistry

The CH oxidative amination of ( Z )‐1‐allylidene‐2‐arylhydrazines with 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO)/ N ‐bromosuccinimide (NBS) provides highly substituted pyrazoles with 100 % regioselectivity in moderate to good yields. These protocols are effective at room temperature and offer a route for the construction of the target five membered heterocycles.

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