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Synthesis of Substituted Pyrazoles from Vinylhydrozones via Bromoamination and Hydroamination with 2,2,6,6‐Tetramethylpiperidine‐1‐oxyl and N ‐Bromosuccinimide
Author(s) -
Sar Dinabandhu,
Paul Rajesh,
Sengoden Mani,
Punniyamurthy Tharmalingam
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201300294
Subject(s) - chemistry , n bromosuccinimide , amination , hydroamination , regioselectivity , oxidative phosphorylation , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis , halogenation , biochemistry
The CH oxidative amination of ( Z )‐1‐allylidene‐2‐arylhydrazines with 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO)/ N ‐bromosuccinimide (NBS) provides highly substituted pyrazoles with 100 % regioselectivity in moderate to good yields. These protocols are effective at room temperature and offer a route for the construction of the target five membered heterocycles.