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Copper‐Catalyzed Trifluoromethylation‐Initiated Radical Oxidative Annulation toward Oxindoles
Author(s) -
Lu Qingquan,
Liu Chao,
Peng Pan,
Liu Zhiliang,
Fu Lijun,
Huang Jinguo,
Lei Aiwen
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201300236
Subject(s) - trifluoromethylation , chemistry , radical , annulation , catalysis , oxidative phosphorylation , copper , organic chemistry , combinatorial chemistry , photochemistry , medicinal chemistry , biochemistry , alkyl , trifluoromethyl
Abstract A copper‐catalyzed radical oxidative trifluoromethylation and arylation of electron‐withdrawing alkenes has been developed, in which economical sodium trifluoromethanesulfinate is used as the CF 3 source. A preliminary kinetic investigation indicated that the generation of CF 3 radicals under the mild conditions might be a facile process.