Copper‐Catalyzed Trifluoromethylation‐Initiated Radical Oxidative Annulation toward Oxindoles | Zendy

Lu Qingquan | Zendy; Liu Chao | Zendy; Peng Pan | Zendy; Liu Zhiliang | Zendy; Fu Lijun | Zendy; Huang Jinguo | Zendy; Lei Aiwen | Zendy

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Copper‐Catalyzed Trifluoromethylation‐Initiated Radical Oxidative Annulation toward Oxindoles

Author(s) -

Lu Qingquan,

Liu Chao,

Peng Pan,

Liu Zhiliang,

Fu Lijun,

Huang Jinguo,

Lei Aiwen

Publication year - 2014

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201300236

Subject(s) - trifluoromethylation , chemistry , radical , annulation , catalysis , oxidative phosphorylation , copper , organic chemistry , combinatorial chemistry , photochemistry , medicinal chemistry , biochemistry , alkyl , trifluoromethyl

A copper‐catalyzed radical oxidative trifluoromethylation and arylation of electron‐withdrawing alkenes has been developed, in which economical sodium trifluoromethanesulfinate is used as the CF 3 source. A preliminary kinetic investigation indicated that the generation of CF 3 radicals under the mild conditions might be a facile process.

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