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Enantioselective Transfer Hydrogenation of Difluoromethyl Ketimines Using Benzothiazoline as a Hydrogen Donor in Combination with a Chiral Phosphoric Acid
Author(s) -
Sakamoto Tsubasa,
Horiguchi Kosaku,
Saito Kodai,
Mori Keiji,
Akiyama Takahiko
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201300174
Subject(s) - enantioselective synthesis , chemistry , phosphoric acid , transfer hydrogenation , organic chemistry , hydrogen , catalysis , combinatorial chemistry , ruthenium
Hold the benzothiazoline : Highly enantioselective transfer hydrogenation of difluoromethyl ketimines with benzothiazolines catalyzed by a chiral phosphoric acid furnishes α‐difluoromethylated amines in good yields and with excellent enantioselectivity, irrespective of the stereochemistry of the starting materials. PMP= p ‐methoxyphenyl.