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Palladium‐Catalyzed CH and CN Arylation of Aminothiazoles with Arylboronic Acids
Author(s) -
Uehara Takahiro N.,
Yamaguchi Junichiro,
Itami Kenichiro
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201300172
Subject(s) - chemistry , catalysis , palladium , cleavage (geology) , medicinal chemistry , combinatorial chemistry , organic chemistry , geotechnical engineering , fracture (geology) , engineering
A C4‐selective CH arylation of 2‐aminothiazoles with arylboronic acids takes place under the influence of Pd(OAc) 2 /phen/TEMPO/LiBF 4 in air. During this study, a Pd‐catalyzed CN cleavage/arylation of 2‐aminobenzothiazoles with arylboronic acids has been discovered. bipy=2,2‐bipyridyl; TEMPO=2,2,6,6‐tetramethylpiperidin‐1‐oxyl.