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Specific Enhancement of Reactivity and Selectivity in the Substitution Reactions of Polyhydroxy Derivatives by Lithium Chloride
Author(s) -
Watanabe Yutaka,
Kawamoto Mao,
Shintaku Hiroyuki,
Tanabe Kae,
Ohta Hidetoshi,
Hayashi Minoru
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201300163
Subject(s) - chemistry , selectivity , diol , intramolecular force , reactivity (psychology) , lithium (medication) , vicinal , hydrogen bond , substitution (logic) , organic chemistry , lithium chloride , substitution reaction , chloride , electrophilic aromatic substitution , medicinal chemistry , catalysis , molecule , medicine , alternative medicine , pathology , computer science , programming language , endocrinology
Diol A for activation: LiCl mediates mono‐ O ‐substitution of vicinal diol derivatives that are capable of forming intramolecular hydrogen bonds. The remarkable selectivity that leads to mono‐ O ‐substitution was demonstrated in polyols such as cyclitols and saccharides. SM=starting material.