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Progress in Designing Artificial Proteases: A New Therapeutic Option for Amyloid Diseases
Author(s) -
Suh Junghun
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201300135
Subject(s) - proteases , chemistry , peptide , amyloid (mycology) , hydrolysis , biochemistry , computational biology , enzyme , biology , inorganic chemistry
This Focus Review describes the evolution of artificial proteases, which are synthetic catalysts for peptide hydrolysis that mimic the action of natural proteases. The evolution took place through discovery of catalytic centers for peptide hydrolysis, attachment of substrate‐recognition sites to the catalytic centers, and the advent of target‐selective artificial proteases. Application of the target‐selective artificial proteases led to a therapeutic option for amyloid diseases, such as Alzheimer’s disease and diabetes.