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Recent Advances in the Use of Chiral Brønsted Acids as Cooperative Catalysts in Cascade and Multicomponent Reactions
Author(s) -
Lv Fengping,
Liu Shunying,
Hu Wenhao
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201300097
Subject(s) - chemistry , enantioselective synthesis , catalysis , brønsted–lowry acid–base theory , organocatalysis , bifunctional , combinatorial chemistry , stereoselectivity , organic chemistry , cascade reaction , heteroatom , organic reaction , atom economy , organic synthesis , ring (chemistry)
In recent years, chiral Brønsted acid catalysts have been widely used in numerous enantioselective carbon–carbon and carbon–heteroatom bond‐forming reactions. Cascade/domino reactions and multicomponent reactions provide highly efficient, operationally simple, and atom‐economical approaches to the synthesis of polyfunctional complex molecules that are useful for modern organic chemistry and drug discovery. The control of stereoselectivity in these reactions remains a great challenge. Chiral Brønsted acid catalysts were rationally introduced as bifunctional catalysts to achieve synergetic catalysis for well‐controlled stereoselectivity. The synergy between chiral Brønsted acid catalysts and other compatible catalysts provides additional avenues for the discovery of novel organic transformations and improves reaction selectivity as well. In this Focus Review, recent advances in the uses of chiral Brønsted acids as cooperative catalysts in asymmetric cascade/multicomponent reactions are summarized.