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Catalytic Enantioselective α‐Chlorination of Carbonyl Compounds
Author(s) -
Shibatomi Kazutaka,
Narayama Akira
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201300058
Subject(s) - enantioselective synthesis , chemistry , stereospecificity , catalysis , alkyl , stereoselectivity , organic chemistry , asymmetric carbon , combinatorial chemistry
Stereoselective construction of chlorinated chiral carbon centers is a highly valuable operation because the resulting chiral chlorides serve as versatile intermediates for producing many chiral molecules by S N 2‐type displacement with inversion of stereochemistry. Despite the synthetic utility of chiral alkyl chlorides, catalytic methods for achieving enantioselective chlorination were only developed in the last ten years. This Focus Review covers the progress of catalytic asymmetric α‐chlorination of carbonyl compounds over the last decade. Some stereospecific transformations of the resulting alkyl chlorides are also introduced.