Oxygen‐promoted Palladium‐on‐Carbon‐catalyzed Ligand‐free Suzuki Reaction for the Synthesis of Heterobiaryls in Aqueous Media | Zendy

Rao Xiaofeng | Zendy; Liu Chun | Zendy; Xing Yang | Zendy; Fu Yao | Zendy; Qiu Jieshan | Zendy; Jin Zilin | Zendy

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Oxygen‐promoted Palladium‐on‐Carbon‐catalyzed Ligand‐free Suzuki Reaction for the Synthesis of Heterobiaryls in Aqueous Media

Author(s) -

Rao Xiaofeng,

Liu Chun,

Xing Yang,

Fu Yao,

Qiu Jieshan,

Jin Zilin

Publication year - 2013

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201300053

Subject(s) - chemistry , catalysis , palladium , ligand (biochemistry) , halide , suzuki reaction , aqueous solution , aqueous medium , oxygen , combinatorial chemistry , molecular oxygen , coupling reaction , organic chemistry , receptor , biochemistry

We report a practical and highly efficient protocol for the synthesis of heterobiaryls by a Pd/C‐catalyzed Suzuki reaction under aqueous, aerobic, and ligand‐free conditions. This ligand‐free catalytic system tolerates a broad range of functional groups in both coupling partners. A variety of heteroaryl halides were coupled with arylboronic acids to give the corresponding heterobiaryls in good to excellent yields. Moreover, the results demonstrated that the Pd/C‐catalyzed heterogeneous Suzuki reaction is promoted by oxygen.

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