Design and Synthesis of Camphor‐derived Chiral [1,2,4]Triazolo[4,3‐ a ]tetrahydroquinoline N‐Heterocyclic Carbene Precursors by Pd‐Catalyzed Coupling Reactions of Aryl Hydrazides with a Pyridyl Triflate Derivative | Zendy

Chen LiangAn | Zendy; Wang ChuanFei | Zendy; Lin MingGui | Zendy; Zhang JinLong | Zendy; Huang PeiQiang | Zendy; Wang AiE | Zendy

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Design and Synthesis of Camphor‐derived Chiral [1,2,4]Triazolo[4,3‐ a ]tetrahydroquinoline N‐Heterocyclic Carbene Precursors by Pd‐Catalyzed Coupling Reactions of Aryl Hydrazides with a Pyridyl Triflate Derivative

Author(s) -

Chen LiangAn,

Wang ChuanFei,

Lin MingGui,

Zhang JinLong,

Huang PeiQiang,

Wang AiE

Publication year - 2013

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201300024

Subject(s) - carbene , chemistry , camphor , aryl , trifluoromethanesulfonate , phosphine , medicinal chemistry , catalysis , ligand (biochemistry) , coupling reaction , combinatorial chemistry , organic chemistry , stereochemistry , alkyl , biochemistry , receptor

Which came first? A Pd‐catalyzed coupling reaction of N‐ tert ‐butyloxycarbonyl (Boc) aryl hydrazines with a camphor‐derived pyridyl triflate derivative has been developed by using bulky electron‐rich phosphine or N‐heterocyclic carbene as the ligand. With this CN coupling reaction as the key step, camphor‐derived chiral [1,2,4]triazolo[4,3‐ a ]tetrahydroquinoline N‐heterocyclic carbene precursors were synthesized. Tf=trifluoromethanesulfonyl.

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