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Brønsted‐Acid‐Catalyzed Regio‐ and Stereoselective Alkenylation and [3+2] Annulation of N ‐Benzylic Sulfonamides with Alkenes
Author(s) -
Li HaiHua,
Zhang Xiang,
Jin YinHuan,
Tian ShiKai
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201300020
Subject(s) - chemistry , stereoselectivity , annulation , alkene , catalysis , organic chemistry , combinatorial chemistry , stereochemistry
Making the switch : Sulfuric acid catalyzes the alkenylation and [3+2] annulation of N ‐benzylic sulfonamides with alkenes depending on the substituents of the alkene (see scheme). Importantly, this approach provides easy access to polysubstituted alkenes and indanes with high regio‐ and stereoselectivity. Ts= p ‐toluenesulfonyl.