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Redox Potential of Nitroxides is an Index to Evaluate Superoxide Dismutase Mimic Activity
Author(s) -
Yamasaki Toshihide,
Matsuoka Yuta,
Mito Fumiya,
Yamato Mayumi,
Yamada Kenichi
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201300011
Subject(s) - chemistry , nitroxide mediated radical polymerization , superoxide dismutase , redox , superoxide , piperidine , reactivity (psychology) , combinatorial chemistry , biochemistry , stereochemistry , enzyme , organic chemistry , medicine , alternative medicine , radical polymerization , pathology , copolymer , polymer
Superoxide dismutase it : The structure‐reactivity relationship of piperidine nitroxides modified at the C4 position against superoxide was evaluated. The redox potential of nitroxides and N ‐oxoammonium cation couples correlates strongly with their reactivity toward superoxide. Thus, the superoxide dismutase activity of a nitroxide can be controlled based on its redox potential.