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Inside Cover: α‐Heterosubstituted β‐Alkylacroleins as Useful Multisubstituted Dienophiles for Enantioselective Diels–Alder Reactions (Asian J. Org. Chem. 2/2012)
Author(s) -
Sakakura Akira,
Yamada Hiroki,
Ishihara Kazuaki
Publication year - 2012
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201290006
Subject(s) - enantioselective synthesis , chemistry , diels–alder reaction , organic chemistry , dipeptide , cover (algebra) , catalysis , combinatorial chemistry , amino acid , mechanical engineering , biochemistry , engineering
α‐Heterosubstituted acroleins are useful dienophiles for enantioselective Diels‐Alder reactions (DARs) catalyzed by chiral organoammonium salts of dipeptide‐derived triamines. Since the enantioselective DAR of α‐(acyloxy)acroleins was developed, Ishihara and co‐workers have used various α‐ and α‐substituted acroleins as dienophiles. Now, as shown in their Communication on page 133 ff. , the DARs of α‐substituted α‐( N , N ‐dialkylcarbamoyloxy)‐ and β‐substituted α‐(acylamino)acroleins give easy access to multisubstituted chiral compounds.