Premium
Palladium‐Catalyzed Decarboxylative Suzuki and Heck Couplings of Azaindole‐2‐carboxylic Acids: Synthesis of 2‐Aryl/Alkenyl‐1‐phenylsulfonyl‐1 H ‐pyrrolo‐[2,3 b]pyridines
Author(s) -
Suresh Rajendran,
Muthusubramanian Shanmugam,
Kumaran Rajendran Senthil,
Manickam Govindaswamy
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201200169
Subject(s) - chemistry , palladium , aryl , heck reaction , catalysis , carboxylic acid , decarboxylation , suzuki reaction , medicinal chemistry , organic chemistry , derivative (finance) , stereochemistry , alkyl , financial economics , economics
A series of 2‐aryl‐1‐(phenylsulfonyl)‐1 H ‐pyrrolo[2,3‐b]pyridines 3 were obtained by a palladium‐catalyzed decarboxylative Suzuki coupling of azaindole‐2‐carboxylic acid derivative 1 . The synthesis of alkenyl‐1‐(phenylsulfonyl)‐1 H ‐pyrrolo[2,3‐b]pyridines 9 by a related Heck coupling is also described. Protodecarboxylation operates in the case of azaindole‐3‐carboxylic acids under the reaction conditions.