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Catalytic Asymmetric Construction of Stereogenic Carbon Centers that Feature a gem ‐Difluoroalkyl Group
Author(s) -
Liu YunLin,
Yu JinSheng,
Zhou Jian
Publication year - 2013
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201200131
Subject(s) - stereocenter , chemistry , carbon atom , catalysis , group (periodic table) , carbon fibers , alkyl , fluorine , feature (linguistics) , hydrogen atom , organic chemistry , stereochemistry , combinatorial chemistry , enantioselective synthesis , linguistics , materials science , philosophy , composite number , composite material
gem ‐Difluoroalkyl groups, characterized as a gem ‐difluoromethylene group substituted by a hydrogen atom or an alkyl or other functional group, are not only valuable for the modulation of the properties of organic compounds, but are also useful for the synthesis of various fluorine‐containing compounds. Currently, the catalytic asymmetric construction of stereogenic carbon centers that feature a gem ‐difluoroalkyl group is in its infancy. This Focus Review summarizes the latest achievements and discusses the difficulties and challenges in this field.