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Versatile and Direct Transformation of Secondary Amides into Ketones by Deaminative Alkylation with Organocerium Reagents
Author(s) -
Xiao KaiJiong,
Wang AiE,
Huang YingHong,
Huang PeiQiang
Publication year - 2012
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201200066
Subject(s) - chemistry , reagent , alkylation , organic chemistry , organic synthesis , alkyl , combinatorial chemistry , ketone , primary (astronomy) , catalysis , physics , astronomy
Cerium makes it simple : A simple, efficient, and versatile CC bond‐forming method for the direct transformation of secondary amides into ketones by Tf 2 O‐mediated deaminative alkylation with organocerium reagents is described. A wide variety of ketones, including α,β ‐unsaturated ketones, β ‐chloroenones, diaryl ketones, and ynones, were synthesized by using this method.