Iron‐Catalyzed  ortho  Monoarylation of Benzamide Derivatives | Zendy

Ilies Laurean | Zendy; Konno Eita | Zendy; Chen Quan | Zendy; Nakamura Eiichi | Zendy

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Iron‐Catalyzed ortho Monoarylation of Benzamide Derivatives

Author(s) -

Ilies Laurean,

Konno Eita,

Chen Quan,

Nakamura Eiichi

Publication year - 2012

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201200042

Subject(s) - benzamide , chemistry , reagent , catalysis , aryl , derivative (finance) , combinatorial chemistry , medicinal chemistry , organic chemistry , business , alkyl , finance

Exclusive! The iron‐catalyzed reaction between a secondary benzamide derivative and a diarylzinc reagent regioselectively substitutes the ortho ‐hydrogen atom of the benzamide with an aryl group. This method exclusively produces an ortho ‐monoarylated product, and none of the diarylated product.“Ph 2 Zn”=2PhMgBr+ZnCl 2 /tetramethylethylenediamine; dtbpy=4,4′‐di‐ tert ‐butyl‐2,2′‐bipyridyl.

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