Premium
Iron‐Catalyzed ortho Monoarylation of Benzamide Derivatives
Author(s) -
Ilies Laurean,
Konno Eita,
Chen Quan,
Nakamura Eiichi
Publication year - 2012
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201200042
Subject(s) - benzamide , chemistry , reagent , catalysis , aryl , derivative (finance) , combinatorial chemistry , medicinal chemistry , organic chemistry , business , alkyl , finance
Exclusive! The iron‐catalyzed reaction between a secondary benzamide derivative and a diarylzinc reagent regioselectively substitutes the ortho ‐hydrogen atom of the benzamide with an aryl group. This method exclusively produces an ortho ‐monoarylated product, and none of the diarylated product.“Ph 2 Zn”=2PhMgBr+ZnCl 2 /tetramethylethylenediamine; dtbpy=4,4′‐di‐ tert ‐butyl‐2,2′‐bipyridyl.