Total Synthesis of Marinoquinoline A Using a Palladium(0)‐Catalyzed Ullmann Cross‐Coupling Reaction | Zendy

Ma Xinghua | Zendy; Vo Yen | Zendy; Banwell Martin G. | Zendy; Willis Anthony C. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Total Synthesis of Marinoquinoline A Using a Palladium(0)‐Catalyzed Ullmann Cross‐Coupling Reaction

Author(s) -

Ma Xinghua,

Vo Yen,

Banwell Martin G.,

Willis Anthony C.

Publication year - 2012

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201200037

Subject(s) - chemistry , palladium , yield (engineering) , catalysis , methanol , ullmann reaction , natural product , magnesium , coupling reaction , coupling (piping) , combinatorial chemistry , organic chemistry , metallurgy , materials science

The title natural product, 1 , has been synthesized. The pivotal steps are a Pd 0 ‐catalyzed Ullmann cross‐coupling of the 3‐iodopyrrole‐2‐carboxaldehyde 13 with o ‐bromonitrobenzene ( 14 ), conversion of the resulting 3‐arylpyrrole 15 into methylketone 17 , and reductive cyclization of 17 by using magnesium in methanol to give target 1 in 85 % yield.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research