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Preparation of Arylbutadiyne Derivatives by Silyl Migration Inspired by the Mukaiyama Protocol
Author(s) -
Shigeta Masayuki,
Watanabe Junji,
Konishi Genichi
Publication year - 2012
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201200018
Subject(s) - chemistry , silylation , protocol (science) , reagent , aldehyde , combinatorial chemistry , transformation (genetics) , world wide web , organic chemistry , computer science , catalysis , gene , medicine , alternative medicine , pathology , biochemistry
One at a time : A one‐pot monodesilylation and arylation of a silyl end‐capped butadiyne is presented. Inspired by the Mukaiyama aldehyde alkynylation protocol, this method furnishes arylbutadiynes, which are potentially useful synthetic intermediates in the synthesis of other complex or linear structures. The transformation is achieved with reagents that are easily handled and avoids the need to isolate highly volatile intermediates.