Indium(III)‐Promoted Organocatalytic Enantioselective  α ‐Alkylation of Aldehydes with Benzylic and Benzhydrylic Alcohols | Zendy

Guiteras Capdevila Montse | Zendy; Emer Enrico | Zendy; Benfatti Fides | Zendy; Gualandi Andrea | Zendy; Wilson Claire M. | Zendy; Cozzi Pier Giorgio | Zendy

Premium

Indium(III)‐Promoted Organocatalytic Enantioselective α ‐Alkylation of Aldehydes with Benzylic and Benzhydrylic Alcohols

Author(s) -

Guiteras Capdevila Montse,

Emer Enrico,

Benfatti Fides,

Gualandi Andrea,

Wilson Claire M.,

Cozzi Pier Giorgio

Publication year - 2012

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201200013

Subject(s) - chemistry , enantioselective synthesis , organocatalysis , indium , diastereomer , stereoselectivity , alkylation , organic chemistry , catalysis , combinatorial chemistry

Best of both worlds : Organocatalytic S N 1‐type reactions promoted by indium(III) salts were performed with activated benzylic and benzhydrylic substrates. High ee values and moderate diastereomeric ratios were obtained. The presence of a 4‐NMe 2 Ph group, which is useful for further transformations, is essential for obtaining high yields. The synergy of indium(III) salts with organocatalysis is a useful strategy for stereoselective transformations.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research