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Approach to overgrowth syndromes in the genome era
Author(s) -
Burkardt Deepika D.,
TattonBrown Katrina,
Dobyns William,
Graham John M.
Publication year - 2019
Publication title -
american journal of medical genetics part c: seminars in medical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.419
H-Index - 101
eISSN - 1552-4876
pISSN - 1552-4868
DOI - 10.1002/ajmg.c.31757
Subject(s) - epigenetics , terminology , neuroscience , bioinformatics , medicine , biology , data science , computer science , genetics , gene , linguistics , philosophy
This introduction to the special issue of AJMG Part C : Overgrowth Syndromes updates the current understanding of overgrowth syndromes. We clarify the terminology associated with overgrowth, review some common pathways to overgrowth and present a preliminary classification based on currently known genomic and epigenetic mechanisms. We introduce the articles of this issue—new research and reviews of well‐established and recently described overgrowth syndromes of the brain, body or both.