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A standardized autopsy protocol for arthrogryposis (multiple congenital contractures)
Author(s) -
Oberg Kerby C.,
Magaki Shino,
Hall Judith G.
Publication year - 2019
Publication title -
american journal of medical genetics part c: seminars in medical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.419
H-Index - 101
eISSN - 1552-4876
pISSN - 1552-4868
DOI - 10.1002/ajmg.c.31731
Subject(s) - arthrogryposis multiplex congenita , arthrogryposis , autopsy , etiology , medicine , muscle contracture , presentation (obstetrics) , pediatrics , physical medicine and rehabilitation , pathology , surgery
Abstract Arthrogryposis multiplex congenita (AMC) describes disorders with multiple joint contractures that arise from neurological, neuromuscular, or mechanical origin. Although impaired fetal movement is the typical clinical presentation, the etiology underlying this phenotype for a number of conditions remains unknown. In an effort to better characterize and define the etiologies underlying these disorders, we recommend a standardized autopsy protocol that will allow for appropriate diagnosis and a methodical approach for examination that will facilitate subsequent study by investigators across disciplines. To further support investigation, we have also established an AMC autopsy registry to bank tissue obtained at autopsy for subsequent study.