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A clinical update on tuberous sclerosis complex‐associated neuropsychiatric disorders (TAND)
Author(s) -
Vries Petrus J.,
Wilde Lucy,
Vries Magdalena C.,
Moavero Romina,
Pearson Deborah A.,
Curatolo Paolo
Publication year - 2018
Publication title -
american journal of medical genetics part c: seminars in medical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.419
H-Index - 101
eISSN - 1552-4876
pISSN - 1552-4868
DOI - 10.1002/ajmg.c.31637
Subject(s) - psychosocial , tuberous sclerosis , medicine , intellectual disability , psychiatry , neuropsychology , clinical practice , psychology , clinical psychology , cognition , physical therapy
Tuberous sclerosis complex (TSC) is associated with a wide range of behavioral, psychiatric, intellectual, academic, neuropsychological, and psychosocial difficulties, which are often underdiagnosed and undertreated. Here, we present a clinical update on TSC‐associated neuropsychiatric disorders, abbreviated as “TAND,” to guide screening, diagnosis, and treatment in practice. The review is aimed at clinical geneticists, genetic counselors, pediatricians, and all generalists involved in the assessment and treatment of children, adolescents and adults with TSC, and related disorders. The review starts with a summary of the construct and levels of TAND, before presenting up‐to‐date information about each level of investigation. The review concludes with a synopsis of current and future TAND research.