Premium
Implementation of pharmacogenetics: The University of Maryland personalized anti‐platelet pharmacogenetics program
Author(s) -
Shuldiner Alan R.,
Palmer Kathleen,
Pakyz Ruth E.,
Alestock Tameka D.,
Maloney Kristin A.,
O'Neill Courtney,
Bhatty Shaun,
Schub Jamie,
Overby Casey Lynnette,
Horenstein Richard B.,
Pollin Toni I.,
Kelemen Mark D.,
Beitelshees Amber L.,
Robinson Shawn W.,
Blitzer Miriam G.,
McArdle Patrick F.,
Brown Lawrence,
Jeng Linda Jo Bone,
Zhao Richard Y.,
Ambulos Nicholas,
Vesely Mark R.
Publication year - 2014
Publication title -
american journal of medical genetics part c: seminars in medical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.419
H-Index - 101
eISSN - 1552-4876
pISSN - 1552-4868
DOI - 10.1002/ajmg.c.31396
Subject(s) - pharmacogenetics , personalized medicine , medicine , genetic testing , medical physics , bioinformatics , genetics , biology , gene , genotype
Despite a substantial evidence base, implementation of pharmacogenetics into routine patient care has been slow due to a number of non‐trivial practical barriers. We implemented a Personalized Anti‐platelet Pharmacogenetics Program (PAP3) for cardiac catheterization patients at the University of Maryland Medical Center and the Baltimore Veterans Administration Medical Center Patients' are offered CYP2C19 genetic testing, which is performed in our Clinical Laboratory Improvement Amendment (CLIA)‐certified Translational Genomics Laboratory. Results are returned within 5 hr along with clinical decision support that includes interpretation of results and prescribing recommendations for anti‐platelet therapy based on the Clinical Pharmacogenetics Implementation Consortium guidelines. Now with a working template for PAP3, implementation of other drug‐gene pairs is in process. Lessons learned as described in this article may prove useful to other medical centers as they implement pharmacogenetics into patient care, a critical step in the pathway to personalized and genomic medicine. © 2014 Wiley Periodicals, Inc.