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Refining the structure and content of clinical genomic reports
Author(s) -
Dorschner Michael O.,
Amendola Laura M.,
Shirts Brian H.,
Kiedrowski Lesli,
Salama Joseph,
Gordon Adam S.,
Fullerton Stephanie M.,
TarczyHornoch Peter,
Byers Peter H.,
Jarvik Gail P.
Publication year - 2014
Publication title -
american journal of medical genetics part c: seminars in medical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.419
H-Index - 101
eISSN - 1552-4876
pISSN - 1552-4868
DOI - 10.1002/ajmg.c.31395
Subject(s) - refining (metallurgy) , computational biology , process engineering , computer science , chemistry , biology , engineering
To effectively articulate the results of exome and genome sequencing we refined the structure and content of molecular test reports. To communicate results of a randomized control trial aimed at the evaluation of exome sequencing for clinical medicine, we developed a structured narrative report. With feedback from genetics and non‐genetics professionals, we developed separate indication‐specific and incidental findings reports. Standard test report elements were supplemented with research study‐specific language, which highlighted the limitations of exome sequencing and provided detailed, structured results, and interpretations. The report format we developed to communicate research results can easily be transformed for clinical use by removal of research‐specific statements and disclaimers. The development of clinical reports for exome sequencing has shown that accurate and open communication between the clinician and laboratory is ideally an ongoing process to address the increasing complexity of molecular genetic testing. © 2014 Wiley Periodicals, Inc.