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The genetics of obsessive compulsive disorder: A review of the evidence
Author(s) -
Pauls David L.
Publication year - 2008
Publication title -
american journal of medical genetics part c: seminars in medical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.419
H-Index - 101
eISSN - 1552-4876
pISSN - 1552-4868
DOI - 10.1002/ajmg.c.30168
Subject(s) - twin study , candidate gene , serotonergic , genetics , genetic linkage , serotonin transporter , obsessive compulsive , genome wide association study , psychology , psychiatry , gene , biology , heritability , genotype , single nucleotide polymorphism , receptor , serotonin
Abstract Obsessive compulsive disorder (OCD) is a common psychiatric disorder that can have disabling effects on both adults and children. Twin, family, segregation, and linkage studies have demonstrated that OCD is familial, that the familiality is due in part to genetic factors and there are regions of the genome which very likely harbor susceptibility loci for OCD. Over 60 candidate gene studies have been conducted. Most studies have focused on genes in the serotonergic and dopaminergic pathways. Unfortunately, none have achieved genome‐wide significance and with the exception of the glutamate transporter gene, none have been reliably replicated. Future research will requite much larger samples and the collaboration of researchers to be able to identify susceptibility loci for OCD. © 2008 Wiley‐Liss, Inc.