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Tolerance for uncertainty and perceived risk among women receiving uninformative BRCA1/2 test results
Author(s) -
O'Neill Suzanne C.,
DeMarco Tiffani,
Peshkin Beth N.,
Rogers Sarah,
Rispoli Jessica,
Brown Karen,
Valdimarsdottir Heiddis,
Schwartz Marc D.
Publication year - 2006
Publication title -
american journal of medical genetics part c: seminars in medical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.419
H-Index - 101
eISSN - 1552-4876
pISSN - 1552-4868
DOI - 10.1002/ajmg.c.30104
Subject(s) - distress , breast cancer , medicine , genetic testing , clinical psychology , genetic counseling , coping (psychology) , risk perception , cancer , psychology , perception , genetics , neuroscience , biology
Women who receive uninformative BRCA1/2 genetic test results face ongoing uncertainty about their future cancer risks. This article prospectively examined the influence of intolerance for uncertainty and perceived breast cancer risk on psychological distress following the receipt of uninformative BRCA1/2 test results. Sixty‐four women who received uninformative BRCA1/2 mutation test results completed measures of Intolerance for Uncertainty, perceived breast cancer risk, and measures of cancer‐related, genetic testing, and general distress. Cancer‐related (ΔR 2  = 0.18, P  ≤ 0.001), general (ΔR 2  = 0.04, P  ≤ 0.05), and genetic testing distress (ΔR 2  = 0.12, P  ≤ 0.01) were associated with intolerance for uncertainty at 1 month post‐disclosure. The interaction of intolerance for uncertainty and breast cancer perceived risk predicted cancer‐related (ΔR 2  = 0.10, P  ≤ 0.001) and genetic testing distress (ΔR 2  = 0.09, P  ≤ 0.01) at 6 months post‐disclosure. Distress was highest among patients with highest perceived risk and intolerance for uncertainty, suggesting that those who have difficulty coping with their ambiguous risk are at risk for long‐term distress. The clinical and research implications of these results are discussed. © 2006 Wiley‐Liss, Inc.

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