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Biochemical findings in common inborn errors of metabolism
Author(s) -
Pasquali Marzia,
Monsen Gavin,
Richardson Leah,
Alston Martha,
Longo Nicola
Publication year - 2006
Publication title -
american journal of medical genetics part c: seminars in medical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.419
H-Index - 101
eISSN - 1552-4876
pISSN - 1552-4868
DOI - 10.1002/ajmg.c.30086
Subject(s) - newborn screening , urine , dehydrogenase , inborn error of metabolism , enzyme , biochemistry , pyruvate carboxylase , metabolism , medicine , chemistry , biology
The application of tandem mass spectrometry (MS/MS) to newborn screening has led to the detection of patients with a wider spectrum of inborn errors of metabolism. A definitive diagnosis can often be established early enough to start treatment before symptoms appear. Here, we review common biochemical findings in disorders caused by deficiency of 3‐methylcrotonyl‐CoA carboxylase, isobutyryl‐CoA dehydrogenase, 2‐methyl‐3‐hydroxybutyryl‐CoA dehydrogenase, 3‐ketothiolase, 2‐methylbutyryl‐CoA dehydrogenase, and medium chain acyl CoA dehydrogenase. The diagnosis of these disorders requires biochemical confirmation by measurement of plasma acylcarnitine profile, urine organic acids, and urine acylglycine profiles followed by measurement of enzyme activity or detection of causative mutations. Early treatment can improve the outcome of these disorders. © 2006 Wiley‐Liss, Inc.