The yield of subtelomeric FISH analysis in the evaluation of autistic spectrum disorders | Zendy

Battaglia Agatino | Zendy; Bonaglia Maria C. | Zendy

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The yield of subtelomeric FISH analysis in the evaluation of autistic spectrum disorders

Author(s) -

Battaglia Agatino,

Bonaglia Maria C.

Publication year - 2006

Publication title -

american journal of medical genetics part c: seminars in medical genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.419

H-Index - 101

eISSN - 1552-4876

pISSN - 1552-4868

DOI - 10.1002/ajmg.c.30077

Subject(s) - subtelomere , autism , fish <actinopterygii> , psychology , audiology , medicine , developmental psychology , genetics , biology , dna , telomere , fishery

To assess the frequency of cryptic subtelomeric rearrangements in children and adolescents with autism spectrum disorders, blood samples were studied using a complete set of subtelomeric FISH probes in 72 children with autism spectrum disorders. All children had normal high resolution karyotype, DNA fra‐X analysis, brain MRI, metabolic work‐up, and physical/neirological examination. Subtelomeric analysis did not detect abnormalities in any of the subjects, suggesting the uselessness of such investigations in individuals with primary autism spectrum disorders. © 2006 Wiley‐Liss, Inc.

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