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Molecular characterization of suicide by microarray analysis
Author(s) -
Gwadry Fuad G.,
Sequeira Adolfo,
Hoke Glenn,
ffrenchMullen Jarlath M.H.,
Turecki Gustavo
Publication year - 2005
Publication title -
american journal of medical genetics part c: seminars in medical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.419
H-Index - 101
eISSN - 1552-4876
pISSN - 1552-4868
DOI - 10.1002/ajmg.c.30046
Subject(s) - commit , microarray , microarray analysis techniques , genetic predisposition , suicide attempt , gene chip analysis , biology , computational biology , gene , psychology , bioinformatics , genetics , poison control , human factors and ergonomics , computer science , medicine , gene expression , medical emergency , database
Several lines of evidence support the idea that individuals who commit suicide have a certain biological predisposition, part of which is given by genes. Studies investigating genetic factors increasing suicide predisposition have been limited by current knowledge of the suicide neurobiology and have typically investigated one or a few genes at a time, whereas it is anticipated that several genes account for the total genetic variance mediating suicide. This review focuses on the advantages and the interest of using the microarray technology to investigate the neurobiology of suicide and discusses, by means of a data analysis example, the possible methodological problems and bioinformatic strategies that should be employed in order to separate the signal from the large amount of background noise, which is usually generated in such studies. Microarray expression studies and related platforms are promising tools to gain better insight into the neurobiology of suicide. © 2005 Wiley‐Liss, Inc.