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The neurobiology of bipolar disorder
Author(s) -
Berns Gregory S.,
Nemeroff Charles B.
Publication year - 2003
Publication title -
american journal of medical genetics part c: seminars in medical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.419
H-Index - 101
eISSN - 1552-4876
pISSN - 1552-4868
DOI - 10.1002/ajmg.c.20016
Subject(s) - bipolar disorder , neuroscience , psychology , cognition
Abstract The neurobiology of bipolar disorder is reviewed. Bipolar disorder is associated with alterations in central nervous system (CNS) function from the level of large‐scale brain circuits to intracellular signal transduction mechanisms. Because of the broad spectrum over which these abnormalities appear, the causative effects are most likely present in the lowest common denominator of all of these systems. Current evidence points to subtle alterations in signal transduction that reverberate downstream both intra‐ and extracellularly to produce the symptoms of bipolar disorder. © 2003 Wiley‐Liss, Inc.