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Genome‐wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type
Author(s) -
Green Elaine K.,
Di Florio Arianna,
Forty Liz,
GordonSmith Katherine,
Grozeva Detelina,
Fraser Christine,
Richards Alexander L.,
Moran Jennifer L.,
Purcell Shaun,
Sklar Pamela,
Kirov George,
Owen Michael J.,
O'Donovan Michael C.,
Craddock Nick,
Jones Lisa,
Jones Ian R.
Publication year - 2017
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32572
Subject(s) - bipolar disorder , locus (genetics) , genetics , schizoaffective disorder , genome wide association study , biology , research diagnostic criteria , schizophrenia (object oriented programming) , gene , psychosis , medicine , psychiatry , single nucleotide polymorphism , genotype , endocrinology , lithium (medication)
Studies have suggested that Research Diagnostic Criteria for Schizoaffective Disorder Bipolar type (RDC‐SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated with RDC‐SABP, we have performed a replication study using independent RDC‐SABP cases ( n = 144) and controls ( n = 6,559), focusing on the 10 loci that reached a p ‐value <10 −5 for RDC‐SABP in the Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder sample. Combining the WTCCC and replication datasets by meta‐analysis (combined RDC‐SABP, n = 423, controls, n = 9,494), we observed genome‐wide significant association at one SNP, rs2352974, located within the intron of the gene TRAIP on chromosome 3p21.31 ( p ‐value, 4.37 × 10 −8 ). This locus did not reach genome‐wide significance in bipolar disorder or schizophrenia large Psychiatric Genomic Consortium datasets, suggesting that it may represent a relatively specific genetic risk for the bipolar subtype of schizoaffective disorder.