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A gene‐based review of RGS4 as a putative risk gene for psychiatric illness
Author(s) -
Schwarz Emanuel
Publication year - 2018
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32547
Subject(s) - schizophrenia (object oriented programming) , candidate gene , modalities , neuroscience , gene , mental illness , biology , psychiatry , psychology , computational biology , bioinformatics , genetics , mental health , social science , sociology
Considerable efforts have been made to characterize RGS4 as a potential candidate gene for schizophrenia. Investigations span across numerous modalities and include explorations of genetic risk associations, mRNA and protein levels in the brain, and functionally relevant interactions with other candidate genes as well as links to schizophrenia relevant neural phenotypes. While these lines of investigations have yielded partially inconsistent findings, they provide a perspective on RGS4 as an important part of a larger biological system contributing to schizophrenia risk. This gene‐based review aims to provide a comprehensive overview of published data from different experimental modalities and discusses the current knowledge of RGS4 's systems‐biological impact on the schizophrenia pathology.