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miR‐149 and miR‐29c as candidates for bipolar disorder biomarkers
Author(s) -
Choi Jason L.,
Kao Patricia F.,
Itriago Elena,
Zhan Yougen,
Kozubek James A.,
Hoss Andrew G.,
Banigan Meredith G.,
Vanderburg Charles R.,
Rezvani Amir H.,
Latourelle Jeanne C.,
Cabral Howard,
Delalle Ivana
Publication year - 2017
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32518
Subject(s) - prefrontal cortex , bipolar disorder , pathogenesis , microrna , anterior cingulate cortex , extracellular vesicles , neuroscience , medicine , pathology , biology , psychology , cognition , genetics , gene , microbiology and biotechnology
Bipolar disorder (BD) is a common, recurring psychiatric illness with unknown pathogenesis. Recent studies suggest that microRNA (miRNA) levels in brains of BD patients are significantly altered, and these changes may offer insight into BD pathology or etiology. Previously, we observed significant alterations of miR‐29c levels in extracellular vesicles (EVs) extracted from prefrontal cortex (Brodmann area 9, BA9) of BD patients. In this study, we show that EVs extracted from the anterior cingulate cortex (BA24), a crucial area for modulating emotional expression and affect, have increased levels of miR‐149 in BD patients compared to controls. Because miR‐149 has been shown to inhibit glial proliferation, increased miR‐149 expression in BA24‐derived EVs is consistent with the previously reported reduced glial cell numbers in BA24 of patients diagnosed with either familial BD or familial major depressive disorder. qPCR analysis of laser‐microdissected neuronal and glial cells from BA24 cortical samples of BD patients verified that the glial, but not neuronal, population exhibits significantly increased miR‐149 expression. Finally, we report altered expression of both miR‐149 and miR‐29c in EVs extracted from brains of Flinders Sensitive Line rats, a well‐validated animal model exhibiting depressive‐like behaviors and glial (astrocytic) dysfunction. These findings warrant future investigations into the potential of using EV miRNA signatures as biomarkers to further enhance the biological definition of BD. © 2017 Wiley Periodicals, Inc.