Premium
APOE gene and neuropsychiatric disorders and endophenotypes: A comprehensive review
Author(s) -
Forero Diego A.,
LópezLeón Sandra,
GonzálezGiraldo Yeimy,
Dries Daniel R.,
PereiraMorales Angela J.,
Jiménez Karen M.,
FrancoRestrepo Juan E.
Publication year - 2018
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32516
Subject(s) - endophenotype , apolipoprotein e , neuroscience , gene , psychology , bioinformatics , biology , medicine , genetics , disease , cognition , pathology
The Apolipoprotein E ( APOE ) gene is one of the main candidates in neuropsychiatric genetics, with hundreds of studies carried out in order to explore the possible role of polymorphisms in the APOE gene in a large number of neurological diseases, psychiatric disorders, and related endophenotypes. In the current article, we provide a comprehensive review of the structural and functional aspects of the APOE gene and its relationship with brain disorders. Evidence from genome‐wide association studies and meta‐analyses shows that the APOE gene has been significantly associated with several neurodegenerative disorders. Cellular and animal models show growing evidence of the key role of APOE in mechanisms of brain plasticity and behavior. Future analyses of the APOE gene might find a possible role in other neurological diseases and psychiatric disorders and related endophenotypes. © 2016 Wiley Periodicals, Inc.