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The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population
Author(s) -
Huang Liang,
Mo Yin,
Sun Xuejin,
Yu Hualin,
Li Hao,
Wu Lichuan,
Li Ming
Publication year - 2016
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32418
Subject(s) - voxel based morphometry , han chinese , gray (unit) , locus (genetics) , psychosis , voxel , allele , snp , population , bipolar disorder , genetic association , brain size , psychiatry , psychology , neuroscience , single nucleotide polymorphism , medicine , genetics , biology , genotype , magnetic resonance imaging , gene , white matter , nuclear medicine , cognition , environmental health , radiology
The SNP rs1006737 in CACNA1C gene has been significantly associated with psychiatric disorders (e.g., schizophrenia and bipolar disorder) in European populations. In Han Chinese, rs1006737 is also strongly associated with schizophrenia, although the effects of the psychosis risk SNP on related brain functions and structures in this population remain unclear. Here, we examined the association of rs1006737 with gray matter volume in a sample of 278 healthy Han Chinese. A whole‐brain voxel‐based morphometry (VBM) analysis revealed a significant association in the region around right superior occipital gyrus (family‐wise error corrected, P = 0.023). Our data provides initial evidence for the involvement of this psychosis genetic risk locus in brain structure variations in Chinese population, and calls for further investigations. © 2016 Wiley Periodicals, Inc.