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Genome‐wide association study with the risk of schizophrenia in a Korean population
Author(s) -
Kim Lyoung Hyo,
Park Byung Lae,
Cheong Hyun Sub,
Namgoong Suhg,
Kim Ji On,
Kim JeongHyun,
Shin JoongGon,
Park Chul Soo,
Kim BongJo,
Kim Jae Won,
Choi IhnGeun,
Hwang Jaeuk,
Shin Hyoung Doo,
Woo SungIl
Publication year - 2016
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32400
Subject(s) - single nucleotide polymorphism , genome wide association study , genetics , schizophrenia (object oriented programming) , genetic association , biology , population , snp , medicine , genotype , gene , psychiatry , environmental health
Schizophrenia is regarded as a multifactorial and polygenic brain disorder that is attributed to different combinations of genetic and environmental risk factors. Recently, several genome‐wide association studies (GWASs) of schizophrenia have identified numerous risk factors, but the replication results remain controversial and ambiguous. To identify schizophrenia susceptibility loci in the Korean population, we performed a GWAS using the Illumina HumanOmni1‐Quad V1.0 Microarray. We genotyped 1,140,419 single nucleotide polymorphisms (SNPs) in 350 Korea schizophrenia patients and 700 control subjects, and approximately 620,001 autosomal SNPs were passed our quality control. In the case–control analysis, the rs9607195 A>G on intergenic area 250 kb away from the ISX gene and the rs12738007 A>G on the intron of the MECR gene were the most strongly associated SNPs with the risk of schizophrenia ( P = 6.2 × 10 −8 , OR = 0.50 and P = 3.7 × 10 −7 , OR = 2.39, respectively). In subsequent fine‐mapping analysis, 6 SNPs of MECR were genotyped with 310 schizophrenia patients and 604 control subjects. The association of the MECR rs12738007, a top ranked‐SNP in GWAS, was replicated ( P = 1.5 × 10 −2 , OR = 1.53 in fine mapping analysis, P = 1.5 × 10 −6 , OR = 1.90 in combined analysis). The identification of putative schizophrenia susceptibility loci could provide new insights into genetic factors related with schizophrenia and clues for the development of diagnosis strategies. © 2015 Wiley Periodicals, Inc.