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Association between DRD2 (rs1799732 and rs1801028) and ANKK1 (rs1800497) polymorphisms and schizophrenia: A meta‐analysis
Author(s) -
Yao Jun,
Pan Yuqing,
Ding Mei,
Pang Hao,
Wang Baojie
Publication year - 2015
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32281
Subject(s) - meta analysis , odds ratio , schizophrenia (object oriented programming) , confidence interval , medicine , case control study , etiology , subgroup analysis , genetic association , oncology , biology , genetics , psychiatry , genotype , gene , single nucleotide polymorphism
The role of dopamine D2 receptor (DRD2) polymorphisms in schizophrenia remains controversial. We performed a meta‐analysis to determine whether DRD2 polymorphisms influence the risk of schizophrenia and examined the relationship between rs1799732, rs1801028, and rs1800rs028 an23381d rs1800497 genetic variants and the etiology of schizophrenia. Relevant case‐control studies were retrieved by database searches and selected according to established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. Meta‐regression, subgroup analysis, sensitivity analysis, and cumulative meta‐analysis were performed. A total of 76 studies with 16096 cases and 18965 controls were included. Specifically, 24 studies with 6075 cases and 6643 controls involved rs1799732, 36 studies with 8043 cases and 10194 controls involved rs1801028 and 16 studies with 1978 cases and 2128 controls involved rs1800497. No significant associations were observed between rs1799732 and rs1800rs732 and rs1800497 and schizophrenia. The rs1801028 locus was associated with schizophrenia, with a pooled OR of 1.221 (95% CI = 1.037–1.438, P = 0.016). This meta‐analysis indicates that the rs1801028 locus may be associated with schizophrenia. These data provide possible references for future case‐control studies related to schizophrenia. © 2014 Wiley Periodicals, Inc.