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Interactions between MAOA and SYP polymorphisms were associated with symptoms of attention—deficit/hyperactivity disorder in Chinese Han subjects
Author(s) -
Gao Qian,
Liu Lu,
Li HaiMei,
Tang YiLang,
Wu ZhaoMin,
Chen Yun,
Wang YuFeng,
Qian QiuJin
Publication year - 2015
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32273
Subject(s) - multifactor dimensionality reduction , attention deficit hyperactivity disorder , proband , monoamine oxidase a , rating scale , psychology , synaptophysin , clinical psychology , case control study , psychiatry , genetics , medicine , gene , genotype , developmental psychology , biology , single nucleotide polymorphism , mutation , receptor , immunohistochemistry , serotonin
As candidate genes of attention—deficit/hyperactivity disorder (ADHD), monoamine oxidase A ( MAOA ), and synaptophysin ( SYP ) are both on the X chromosome, and have been suggested to be associated with the predominantly inattentive subtype (ADHD‐I). The present study is to investigate the potential gene–gene interaction (G × G) between rs5905859 of MAOA and rs5906754 of SYP for ADHD in Chinese Han subjects. For family‐based association study, 177 female trios were included. For case‐control study, 1,462 probands and 807 normal controls were recruited. The ADHD Rating Scale‐IV (ADHD‐RS‐IV) was used to evaluate ADHD symptoms. Pedigree‐based generalized multifactor dimensionality reduction (PGMDR) for female ADHD trios indicated significant gene interaction effect of rs5905859 and rs5906754. Generalized multifactor dimensionality reduction (GMDR) indicated potential gene–gene interplay on ADHD RS‐IV scores in female ADHD‐I. No associations were observed in male subjects in case‐control analysis. In conclusion, our findings suggested that the interaction of MAOA and SYP may be involved in the genetic mechanism of ADHD‐I subtype and predict ADHD symptoms. © 2014 Wiley Periodicals, Inc.