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Convergent functional genomics of psychiatric disorders
Author(s) -
Niculescu Alexander B.
Publication year - 2013
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32163
Subject(s) - genomics , functional genomics , disease , computational biology , biology , population , genome , medicine , genetics , gene , pathology , environmental health
Genetic and gene expression studies, in humans and animal models of psychiatric and other medical disorders, are becoming increasingly integrated. Particularly for genomics, the convergence and integration of data across species, experimental modalities and technical platforms is providing a fit‐to‐disease way of extracting reproducible and biologically important signal, in contrast to the fit‐to‐cohort effect and limited reproducibility of human genetic analyses alone. With the advent of whole‐genome sequencing and the realization that a major portion of the non‐coding genome may contain regulatory variants, Convergent Functional Genomics (CFG) approaches are going to be essential to identify disease‐relevant signal from the tremendous polymorphic variation present in the general population. Such work in psychiatry can provide an example of how to address other genetically complex disorders, and in turn will benefit by incorporating concepts from other areas, such as cancer, cardiovascular diseases, and diabetes. © 2013 Wiley Periodicals, Inc.