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Next‐generation sequencing in schizophrenia and other neuropsychiatric disorders
Author(s) -
Schreiber Matthew,
Dorschner Michael,
Tsuang Debby
Publication year - 2013
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32156
Subject(s) - schizophrenia (object oriented programming) , exome sequencing , disease , dna sequencing , presentation (obstetrics) , whole genome sequencing , medicine , psychiatry , biology , genome , genetics , mutation , gene , radiology , pathology
Schizophrenia is a debilitating lifelong illness that lacks a cure and poses a worldwide public health burden. The disease is characterized by a heterogeneous clinical and genetic presentation that complicates research efforts to identify causative genetic variations. This review examines the potential of current findings in schizophrenia and in other related neuropsychiatric disorders for application in next‐generation technologies, particularly whole‐exome sequencing (WES) and whole‐genome sequencing (WGS). These approaches may lead to the discovery of underlying genetic factors for schizophrenia and may thereby identify and target novel therapeutic targets for this devastating disorder. © 2013 Wiley Periodicals, Inc.