Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9 | Zendy

Ayub Muhammad | Zendy; Irfan Muhammad | Zendy; Maclean Alan | Zendy; Naeem Farooq | Zendy; Blackwood Douglas | Zendy

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Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9

Author(s) -

Ayub Muhammad,

Irfan Muhammad,

Maclean Alan,

Naeem Farooq,

Blackwood Douglas

Publication year - 2013

Publication title -

american journal of medical genetics part b: neuropsychiatric genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.393

H-Index - 126

eISSN - 1552-485X

pISSN - 1552-4841

DOI - 10.1002/ajmg.b.32126

Subject(s) - microsatellite , linkage (software) , genetics , depression (economics) , genetic linkage , inbreeding depression , chromosome , biology , gene , medicine , inbreeding , population , environmental health , allele , macroeconomics , economics

A large family with a high prevalence of recurrent major depression and high average inbreeding coefficient was ascertained from rural Pakistan. Subjects were interviewed and diagnosed by a trained psychiatrist, 370 microsatellite markers were genotyped and the program FEstim was used for homozygosity mapping. Significant linkage was found on Chromosome 9 and Chromosome 6 after fine mapping. These regions on Chromosome 6 and 9 may harbor genes which predispose to depression. © 2012 Wiley Periodicals, Inc.

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