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Gene expression changes in peripheral blood from chinese han patients with tourette syndrome
Author(s) -
Lei Jing,
Xu Hongbo,
Liang Hui,
Su Linyan,
Zhang Jie,
Huang Xian,
Song Zhi,
Le Weidong,
Deng Hao
Publication year - 2012
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32103
Subject(s) - gene , gene expression , biology , pathogenesis , biomarker , microbiology and biotechnology , genetics , immunology
To evaluate whether gene expression in chromosome 15q13–q22.3 region is responsible for the development of Tourette syndrome (TS). Eighty‐four unrelated Chinese Han patients with TS (male/female = 68/16; mean age 9.92 ± 3.98 years) and 100 sex, age, and ethnicity matched normal controls (male/female = 80/20; mean age 10.90 ± 5.86 years) were enrolled in this study. We performed quantitative real‐time PCR on a subset of seven genes: the L ‐histidine decarboxylase gene ( HDC ), the HECT domain and RCC‐1 like domain 1 gene ( HERC1 ), the HECT domain and RCC‐1 like domain 2 gene ( HERC2 ), the cholinergic receptor, neuronal nicotinic alpha polypeptide 7 gene ( CHRNA7 ), the ubiquitin protein ligase E3A gene ( UBE3A ), the ubiquitin specific peptidase 3 gene ( USP3 ) and the amyloid precursor protein‐binding protein A2 gene ( APBA2 ) previously reported to be stably expressed in brain tissue. A significant difference was shown for the APBA2 gene expression of peripheral lymphocytes between Chinese Han TS group and healthy controls (relative expression: 0.21 ± 0.16‐fold decrease in patients versus normal, P < 0.01). Indicating that the APBA2 gene is a promising peripheral blood biomarker that discriminates between patients with TS and healthy subjects. Further studies into this gene and its protein products may provide insights into the pathogenesis of TS. © 2012 Wiley Periodicals, Inc.