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Biochemical and genetic analyses of childhood attention deficit/hyperactivity disorder
Author(s) -
Caylak Emrah
Publication year - 2012
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32077
Subject(s) - impulsivity , attention deficit hyperactivity disorder , serotonergic , etiology , neurodevelopmental disorder , psychology , dopaminergic , genetic linkage , psychiatry , monoaminergic , neuroscience , clinical psychology , dopamine , medicine , genetics , autism , gene , serotonin , biology , receptor
Attention deficit/hyperactivity disorder (ADHD) in children is a neurobehavioral disorder characterized by inattention, hyperactivity, and/or impulsivity. The biochemical abnormalities and genetic factors play significant roles in the etiology of ADHD. These symptoms affect the behavior performance and social relationships of children in school and at home. Recently, many studies about biochemical abnormalities in ADHD have been published. Several research groups have also suggested the genetic contribution to ADHD, and attempted to identify susceptibility and candidate genes for this disorder through the genetic linkage and association studies. To date, these studies have reported substantial evidence implicating several genes (dopaminergic: DRD4 , DAT1 , DRD5 , COMT ; noradrenergic: DBH , ADRA2A ; serotonergic: 5‐HTT , HTR1B , HTR2A ; cholinergic: CHRNA4 , and central nervous system development pathway: SNAP25 , BDNF ) in the etiology of ADHD. Understanding the biochemistry and genetics of ADHD will allow us to provide a useful addition with other treatment procedures for ADHD. © 2012 Wiley Periodicals, Inc.