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Association study of serotonin pathway genes in attempted suicide
Author(s) -
Judy Jennifer T.,
Seifuddin Fayaz,
Mahon Pamela B.,
Huo Yuqing,
Goes Fernando S.,
Jancic Dubravka,
Schweizer Barbara,
Mondimore Francis M.,
MacKin Dean F.,
DePaulo J. Raymond,
Gershon Elliot S.,
McMahon Francis J.,
Cutler David J.,
Zandi Peter P.,
Potash James B.,
Willour Virginia L.
Publication year - 2012
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.32008
Subject(s) - single nucleotide polymorphism , haplotype , heritability , genetics , missing heritability problem , serotonergic , snp , genetic association , biology , twin study , gene , mood disorders , candidate gene , genotype , psychology , psychiatry , serotonin , anxiety , receptor
Epidemiological studies, such as family, twin, and adoption studies, demonstrate the presence of a heritable component to both attempted and completed suicide. Some of this heritability is accounted for by the presence of comorbid psychiatric disorders, but the evidence also indicates that a portion of this heritability is specific to suicidality. The serotonergic system has been studied extensively in this phenotype, but findings have been inconsistent, possibly due to the presence of multiple susceptibility variants and/or gene–gene interactions. In this study, we genotyped 174 tag and coding single nucleotide polymorphisms (SNPs) from 17 genes within the serotonin pathway on 516 subjects with a major mood disorder and a history of a suicide attempt (cases) and 515 healthy controls, with the goal of capturing the common genetic variation across each of these candidate genes. We tested the 174 markers in single‐SNP, haplotype, gene‐based, and epistasis analyses. While these association analyses identified multiple marginally significant SNPs, haplotypes, genes, and interactions, none of them survived correction for multiple testing. Additional studies, including assessment in larger sample sets and deep resequencing to identify rare causal variants, may be required to fully understand the role that the serotonin pathway plays in suicidal behavior. © 2011 Wiley Periodicals, Inc.