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No evidence that extended tracts of homozygosity are associated with Alzheimer's disease
Author(s) -
Sims Rebecca,
Dwyer Sarah,
Harold Denise,
Gerrish Amy,
Hollingworth Paul,
Chapman Jade,
Jones Nicola,
Abraham Richard,
Ivanov Dobril,
Pahwa Jaspreet Singh,
Moskvina Valentina,
Dowzell Kimberley,
Thomas Charlene,
Stretton Alexandra,
Lovestone Simon,
Powell John,
Proitsi Petroula,
Lupton Michelle K.,
Brayne Carol,
Rubinsztein David C.,
Gill Michael,
Lawlor Brian,
Lynch Aoibhinn,
Morgan Kevin,
Brown Kristelle S.,
Passmore Peter A.,
Craig David,
McGuiness Bernadette,
Todd Stephen,
Johnston Janet A.,
Holmes Clive,
Mann David,
Smith A. David,
Love Seth,
Kehoe Patrick G.,
Hardy John,
Mead Simon,
Fox Nick,
Rossor Martin,
Collinge John,
Livingston Gill,
Bass Nicholas J.,
Gurling Hugh,
McQuillin Andrew,
Jones Lesley,
Holmans Peter A.,
O'Donovan Michael,
Owen Michael J.,
Williams Julie
Publication year - 2011
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.31216
Subject(s) - disease , disease gene identification , biology , genetics , single nucleotide polymorphism , runs of homozygosity , alzheimer's disease , early onset alzheimer's disease , genotype , medicine , gene , pathology , mutation , exome sequencing
Abstract We sought to investigate the contribution of extended runs of homozygosity in a genome‐wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease. © 2011 Wiley‐Liss, Inc.